Therapeutic aptamers: developmental potential as anticancer drugs
نویسندگان
چکیده
منابع مشابه
Therapeutic aptamers: developmental potential as anticancer drugs
Aptamers, composed of single-stranded DNA or RNA oligonucleotides that interact with target molecules through a specific three-dimensional structure, are selected from pools of combinatorial oligonucleotide libraries. With their high specificity and affinity for target proteins, ease of synthesis and modification, and low immunogenicity and toxicity, aptamers are considered to be attractive mol...
متن کاملPerspective: Aptamers as Drugs
Aptamers are nucleic acid molecules, either single-stranded RNA or DNA, that form secondary structures capable of eliciting affinities to a variety of targets ranging from small organics to whole proteins. They can be quickly developed and are relatively inexpensive to manufacture. Aptamers have the potential to be used as novel drug products, but lacks general acceptance within the pharmaceuti...
متن کاملPotential Therapeutic Strategies for Hypertension-Exacerbated Cardiotoxicity of Anticancer Drugs
Despite their recognized cardiotoxic effects, anthracyclines remain an essential component in many anticancer regimens due to their superior antitumor efficacy. Epidemiologic data revealed that about one-third of cancer patients have hypertension, which is the most common comorbidity in cancer registries. The purpose of this review is to assess whether anthracycline chemotherapy exacerbates car...
متن کاملDiscovery of ‘click’ 1,2,3-triazolium salts as potential anticancer drugs
BACKGROUND In order to increase the effectiveness of cancer treatment, new compounds with potential anticancer activities are synthesized and screened. Here we present the screening of a new class of compounds, 1-(2-picolyl)-, 4-(2-picolyl)-, 1-(2-pyridyl)-, and 4-(2-pyridyl)-3-methyl-1,2,3-triazolium salts and 'parent' 1,2,3-triazole precursors. METHODS Cytotoxic activity of new compounds wa...
متن کاملAptamers as Both Drugs and Drug-Carriers
Aptamers are short nucleic acid oligos. They may serve as both drugs and drug-carriers. Their use as diagnostic tools is also evident. They can be generated using various experimental, theoretical, and computational techniques. The systematic evolution of ligands by exponential enrichment which uses iterative screening of nucleic acid libraries is a popular experimental technique. Theory inspir...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMB Reports
سال: 2015
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2015.48.4.277